Extensive bioassays demonstrate that DermaPhage® CA safely and effectively controls C. acnes growth in a highly species-specific manner, preserving neighboring beneficial microbes associated with a balanced, healthy skin microbiome. DermaPhage® CA potently reduces the formation of pernicious C. acnes biofilms and the production of a primary inflammatory mediator common in irritated skin.
In clinical trials, DermaPhage® CA significantly reduced porphyrins and sebum on the face. By controlling the harmful C. acnes populations on the skin, DermaPhage® CA addresses microbial imbalances to reduce blemished features significantly.
Are you interested in learning more? Contact the Biocogent team at info@biocogent.com.
Keywords: Skin microbiome, active ingredient, biofilm, anti-blemish, anti-inflammatory
References & additional reading
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2 Kong, H. H. & Segre, J. A. Skin microbiome: looking back to move forward. J Invest Dermatol 132, 933-939, doi:10.1038/jid.2011.417 (2012).
3 Chen, Y. E., Fischbach, M. A. & Belkaid, Y. Skin microbiota-host interactions. Nature 553, 427-436, doi:10.1038/nature25177 (2018).
4 Barnard, E., Shi, B., Kang, D., Craft, N. & Li, H. The balance of metagenomic elements shapes the skin microbiome in acne and health. Sci Rep 6, 39491, doi:10.1038/srep39491 (2016).
5 Dreno, B. et al. Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. J Eur Acad Dermatol Venereol 32 Suppl 2, 5-14, doi:10.1111/jdv.15043 (2018).
6 Johnson, T., Kang, D., Barnard, E. & Li, H. Strain-level differences in porphyrin production and regulation in Propionibacterium acnes elucidate disease associations. mSphere 1, doi:10.1128/mSphere.00023-15 (2016).
7 Nazipi, S., Stodkilde-Jorgensen, K., Scavenius, C. & Bruggemann, H. The skin bacterium Propionibacterium acnes employs two variants of hyaluronate lyase with distinct properties. Microorganisms 5, doi:10.3390/microorganisms5030057 (2017).
8 Jahns, A. C. et al. An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study. Br J Dermatol 167, 50-58, doi:10.1111/j.1365-2133.2012.10897.x (2012).
9 Coenye, T., Spittaels, K. J. & Achermann, Y. The role of biofilm formation in the pathogenesis and antimicrobial susceptibility of Cutibacterium acnes. Biofilm 4, 100063, doi:10.1016/j.bioflm.2021.100063 (2022).