February 22, 2024 FLSCC Meeting, Daytona Beach, Florida

Thank you so much to all who joined us in Daytona Beach!!

Title: Beyond DNA Damage: Analysis of Cellular and Skin Damage from UV and High-Energy Visible Light

Abstract: UVA, UVB and high-energy visible light (HEV - blue light) are well known to induce DNA damage.  Beyond DNA breakage, thymine dimer formation and DNA oxidation, these wavelengths cause a variety of cellular dysfunction and changes in the dermis and the epidermis.  Matrix degrading enzymes are upregulated, leading to a significant alteration of the dermis.  The cellular circadian rhythm is affected.  Oxygen species and oxidative stress accumulate through a disruption of the functioning of the overall cell and the mitochondria.  There is an increase in inflammation.  At a macro level, dryness occurs, and a loss of biomechanical properties leads to the clinical signs of solar elastosis and premature aging.  This presentation will cover these topics and related in vitro and in vivo tests for a better understanding of the wide range of detriments UV and HEV causes at a cellular and macro level.  The role of inflammation and the process of skin recovery and healing after sunlight exposure will also be covered.

Speaker : Philip Ludwig, Technical Service for Personal Care Actives, North America

Philip holds a MS in Cell and Molecular Biology from Michigan State University and has been with BASF for 8 years working with R&D and customers to provide new skin and hair care actives.  When working in R&D, his last three products won five international awards at PCHi and In-Cosmetics for being either a best new ingredient or most innovative.   Philip has written multiple patents and over a dozen research articles relating to new personal care ingredients.  He has been a featured speaker at dozens of industry events and seminars.  He was awarded the Hans Schaeffer award in 2020 and 2021 for presenting the most innovative cosmetic science paper.