Diglycerin and Polyglyceryl-2 Laurate as a Non-Antibiotic Therapeutic Alternative - Presented by Jim Mosbaugh

Event Date: March 11th, 6-8 pm EST

Date and Time: March 11^th, 2026; 6 - 8 PM

Where: Slyman's Tavern Independence
6901 Rockside Rd, Independence, OH 44131

Presenter: Jim Mosbaugh

Agenda: 6 PM - Arrive, networking and dinner; 7 PM - Presentation

Abstract:

The rise of antimicrobial resistance (AMR) has necessitated the development of alternatives to traditional antibiotic monotherapies, particularly for localized skin and nail infections. Conventional antibiotics often face challenges such as limited efficacy against biofilms and the potential for inducing resistance.  Diglycerin and Polyglyceryl-2 Laurate is a plant-based multifunctional ingredient, and a viable alternative due to its dual antimicrobial and anti-inflammatory properties.

Diglycerin and Polyglyceryl-2 Laurate was evaluated for its ability to inhibit common pathogens and reduce clinical signs of inflammation. In vitro Minimum Inhibitory Concentration (MIC) tests and Suspension Time-Kill (STK) assays were utilized to determine efficacy against Gram-positive bacteria and fungi. Its anti-inflammatory potential was assessed through clinical observations of "skin calming" actions, resolution of localized redness and swelling, and in vitro ELISA studies to determine effect on specific cytokine release suppression.

Diglycerin and Polyglyceryl-2 Laurate blend demonstrates potent antimicrobial activity, effectively reducing loads of Staphylococcus aureus, Cutibacterium acnes, and Candida albicans. Unlike traditional antibiotics that aim for total eradication, diglycerin and polyglyceryl-2 laurate blend mimics innate skin defenses to suppress microbial growth below virulent "quorum" thresholds. Furthermore, it exhibits significant anti-inflammatory (skin-calming) effects, resolving red bumps, minor wounds, and "microbial flare-ups" without the irritation common in conventional treatments. In customer trials for nail fungus, 94% of subjects showed improvement within six weeks.

Diglycerin and Polyglyceryl-2 Laurate serves as a promising alternative to antibiotic monotherapies for topical applications. By combining selective antimicrobial action with inherent anti-inflammatory benefits, it effectively manages infections while promoting a healthy skin microbiome and reducing the risk of developing antimicrobial resistance. Its non-irritating nature makes it particularly suitable for patients with sensitive skin or persistent, recurring infections.

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