Elena Draganoiu, PhD

Achieving Differentiation in Oral Care Products: Long Lasting Formulations Through Mucoadhesion

Title

Achieving Differentiation in Oral Care Products: Long Lasting Formulations Through Mucoadhesion

Presented By

Elena Draganoiu, PhD

Lubrizol Life Sciences

Presentation Time

11:00-11:30AM

Abstract

The development of differentiated oral care products addresses the consumers’ need and preference for long lasting effects. Mucoadhesive dosage forms for the oral cavity can provide enhanced benefits through prolonged retention of actives or flavors, acting as lubricating agents, and coating and protecting damaged tissues (lesions of the oral mucosa).The design of such products requires the use of excipients that impart mucoadhesive properties and ensures prolonged contact between the product and the oral mucosa. Case studies have been developed to demonstrate the value that mucoadhesion technology brings for differentiated oral care products. Various oral care ingredients and formulations have been tested by a method based on the in vitro oesophageal retention (IVOR) model that allows for mucoadhesion evaluation in a dynamic environment. A comparative evaluation of various materials (carbomers, carrageenan, cellulosics, copolymer of methyl vinyl ether and maleic anhydride, xanthan) in simple gel systems indicated significant differences in retention time (from <1 minute, to > 30 minutes).

Enhanced retention through the use of mucoadhesive ingredients was demonstrated for:

· A mouthwash containing thymol, eucalyptol, methyl salicylate and menthol, with other potential benefits like lubrication to help with xerostomia and cytoprotection for mucositis.

· An oral gel containing Sanqi (Panax notoginseng extract), a Traditional Chinese Medicine with hemostatic and anti-inflammatory properties.

· Oral films as a convenient form to deliver actives or flavors to the oral cavity.

The case studies conducted illustrate how differentiation in the market can be achieved with strategic ingredient selection, allowing for product innovation and new label claim opportunities.

Meet the Speaker

Elena Draganoiu is Global Technical Business Development Director, Pharmaceutical & Nutraceutical with Lubrizol Life Science. A pharmacist by training, she obtained her Ph.D. in Pharmaceutics – Industrial Pharmacy from University of Cincinnati and has over 25 years of practice, working in hospital pharmacy, academia and industry. Elena has extensive experience in research and development of ingredients for controlled release, mucosal delivery, solubilization and various dosage forms design. Currently she is responsible for leading Lubrizol’s global technical business development programs pertaining to ingredients for pharmaceutical, oral care and nutraceutical applications.