SCC: Ontario Chapter Lunch Meeting

November 6, 2025 12:30pm @ The Venetian, Vaughan Ontario

Abstract:

Confocal Raman microscopy (CRM) is a vibrational spectroscopy-based technique widely used across various scientific fields, including biology, chemistry, forensics and diagnostics. In the context of skin research, this technique has proven to be invaluable due to its chemically selective nature, non-destructive sample analysis and high spatial resolution in 3D. In penetration and delivery sciences, CRM offers an alternative method for tracking the delivery of active ingredients, presenting a less labour-intensive option compared to the traditional HPLC based tape-tripping method. At DECIEM, CRM forms an integral part of understanding the functionality of our ingredients in the skin as well as in formulation. Its versatility is fully utilized in developing the penetration profiles of actives in real world scenarios and in analysing penetration rate between similar formulations. We have made considerable progress in developing novel in-house CRM based methods. For instance, we routinely use an in-house CRM method to elucidate the hydration effects of moisturizing formulations. We are also studying the effect of co-application of two formulations in a regimen using CRM – which provides insights into optimal regimen combinations for enhanced penetration of both actives. We have expanded our Raman expertise to analyze barrier based studies, evaluating the barrier repair effects of certain formulations. These investigations demonstrate the versatility of this technique and highlight the vast potential CRM holds in the field of cosmeto-sciences.

Biography:

Dr. Ayush Chowdhry is the Acting Principal Scientist, Delivery Sciences, Clinical Research (Global) at DECIEM, where he plays a key role in advancing delivery technologies to support the company’s new product development initiatives. With over 3 years of experience at DECIEM, Ayush has demonstrated a remarkable career progression from Scientist II to Senior Scientist and now to Acting Principal Scientist. As a Subject Matter Expert (SME) in Delivery Sciences, Ayush spearheaded the establishment of delivery science capabilities at DECIEM, employing Confocal Raman Microscopy (CRM) to deepen the understanding of delivery mechanisms in skin and related tissues. His expertise guides a small team of gifted scientists, mentoring their growth and developing their skills to drive innovation within the department. Dr. Chowdhry holds a B.Tech and M.Tech in Biotechnology, alongside a PhD in Biotechnology with a specialization in Stem Cells and Tissue Engineering. His passion for science underpins his achievements, and his leadership reflects a strong blend of technical expertise and a forward-thinking approach. Ayush is committed to strengthening delivery science at DECIEM, helping translate cutting-edge research into impactful, consumer-centric products. 

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