Join/Renew Membership for SCC

Become part of our community of dedicated professional and student members today — join now.

New Members

Download Member ApplicationNew SCC Members may register online or download a writable .PDF membership application and email to Colleen Daddino at cdaddino@scconline.org. All major credit cards are accepted. Please use this form to type all your information. Once complete, please save the file on your computer, then email Colleen Daddino at cdaddino@scconline.org or fax it to (212) 668-1504. The Society prefers typed applications over handwritten for ease of processing. Incomplete applications will delay the processing of your membership.

Existing SCC Members

Current SCC Members can easily renew online. Please take the time to renew your membership today to avoid reinstatement fees and any interruption in benefits.

Stability Studies and Characterization of Glutathione-Loaded Nanoemulsion

Journal of Cosmetic Science | Vol. 69 No. 4
Authored by Naveed Ullah Khan, Atif Ali, Hira Khan, Zaheer Ullah Khan and Zia Ahmedka

Synopsis

Glutathione reduced (GSH) is the mother of all the antioxidants and has an antimelanogenic effect. It is extremely vulnerable to oxidation in the solution form which limits its use. The GSH in nano-oil droplets present a potential solution to this problem. The aim of this study was to formulate glutathione-loaded nanoemulsion and assess its stability studies over a 90-day testing period. To formulate GSH-loaded nanoemulsion pseudo-ternary phase diagram, it was built with various concentrations of water, liquid paraffin oil, and surfactant mixture (Tween 80 and Span 80). The oily phase was prepared by dissolving the GSH (450 mg) in liquid paraffin oil through stirring. High-energy homogenization was used to prepare the nanoemulsion. From preformulation stability studies of the 28-day testing period, nanoemulsion (NE-19) with oil and surfactant mixture ratio (1∶1) of hydrophilic lipophilic balance (HLB) value 10 was selected. The samples of NE-19 and its respective base (B-19) were kept at four different storage conditions for a period of 90 days and evaluated for physical characteristics, droplet size and distribution analysis, zeta potential analysis, electrical conductivity, mobility, polydispersity, pH, phase separation, and flow analysis at different time intervals. Glutathione in nano-oil droplets with nonionic surfactants produced oil-in-water nanoemulsions that were thermodynamically stable over the 90-day testing period at different storage conditions. NE-19 was formulated having non-Newtonian flow and pseudo-plastic behavior. pH was found in the range of 5–6. Polydispersity was less than 0.3. The droplet size of fresh nanoemulsion was 96.05 nm, whereas the zeta potential was −37.1. Mobility and electrical conductivity were −2.726 µm cm\/Vs and 0.0141 mS\/cm, respectively. Glutathione-loaded nanoemulsions have excellent stability, promising the solution in nano-oil droplets and are suggested for in-vivo release studies for oxidative skin related diseases.

For the Full Article, click here